Esr1^tm2.1Ics
Targeted Allele Detail

Summary

• Symbol: Esr1^tm2.1Ics
• Name: estrogen receptor 1 (alpha); targeted mutation 2.1, Mouse Clinical Institute
• MGI ID: MGI:7545668
• Synonyms: ERalpha^S122A
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm2.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341601
• Parent Cell Line: BD10 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting construct inserted a T to G mutation in exon 2 responsible for the amino acid substitution of serine with alanine at position 122 (S122A). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon 2. (J:341601)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 72 strains or lines available

References

• Original: J:341601 Ohlsson C, et al., Phosphorylation site S122 in estrogen receptor alpha has a tissue-dependent role in female mice. FASEB J. 2020 Dec;34(12):15991-16002
• All: 2 reference(s)