Sf3b4^em2.1Lajm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sf3b4^em2.1Lajm
• Name: splicing factor 3b, subunit 4; endonuclease-mediated mutation 2.1, Loydie A Jerome-Majewska
• MGI ID: MGI:7545576
• Gene: Sf3b4 Location: Chr3:96079822-96084880 bp, + strand Genetic Position: Chr3, 41.65 cM
• Alliance: Sf3b4^em2.1Lajm page

Mutation origin

• Strain of Origin: C3H and C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sf3b4^em1Lajm zygotes were targeted to insert a second loxP site into intron 3 via CRISPR/Cas9 technology resulting in an exon 2-3 floxed allele. Exons 2-3 were deleted via cre-mediated recombination. (J:338694)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sf3b4 Mutation: 24 strains or lines available

References

• Original: J:338694 Kumar S, et al., Sf3b4 regulates chromatin remodeler splicing and Hox expression. Differentiation. 2023 May-Jun;131:59-73
• All: 2 reference(s)