Brcc3^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Brcc3^em1Bcgen
• Name: BRCA1/BRCA2-containing complex, subunit 3; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7545514
• Synonyms: Brcc3^-
• Gene: Brcc3 Location: ChrX:74460234-74497607 bp, + strand Genetic Position: ChrX, 38.22 cM
• Alliance: Brcc3^em1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted a 19 kb fragment encompassing exons 3 through 6. Immunoblot analysis confirmed the absence of protein expression in the heart, liver, spleen, lung and kidney of homozygous mutant mice. (J:277205)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brcc3 Mutation: 11 strains or lines available

References

• Original: J:277205 Ren G, et al., ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. EMBO J. 2019 Mar 15;38(6)
• All: 5 reference(s)