Fuca1^tm1.1Rya
Targeted Allele Detail

Summary

• Symbol: Fuca1^tm1.1Rya
• Name: fucosidase, alpha-L- 1, tissue; targeted mutation 1.1, Kevin M Ryan
• MGI ID: MGI:7543911
• Gene: Fuca1 Location: Chr4:135648037-135667611 bp, + strand Genetic Position: Chr4, 68.01 cM, cytoband D3
• Alliance: Fuca1^tm1.1Rya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341790
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and a neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 4. (J:341790)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fuca1 Mutation: 30 strains or lines available

References

• Original: J:341790 Baudot AD, et al., Glycan degradation promotes macroautophagy. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2111506119
• All: 1 reference(s)