Grin2b^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Grin2b^tm1.1Bcgen
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:7543572
• Synonyms: Grin2b^C456Y
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289555
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting vector introduced an FRT-flanked neomycin resistance cassette into intron 5 and replaced exon 6 with a modified one with the mutation responsible for the amino acid substitution cysteine with tyrosine atposition 456 (C456Y). Flp-mediated recombination removed the selection cassette. (J:289555)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 100 strains or lines available

References

• Original: J:289555 Shin W, et al., Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice. PLoS Biol. 2020 Apr;18(4):e3000717
• All: 4 reference(s)