Grm1^em2Yazu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grm1^em2Yazu
• Name: glutamate receptor, metabotropic 1; endonuclease-mediated mutation 2, Michisuke Yuzaki
• MGI ID: MGI:7543450
• Gene: Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
• Alliance: Grm1^em2Yazu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNA induced an 5 bp deletion (c.790_794del) resulting in a frameshift mutation and premature stop codon. (J:341707)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm1 Mutation: 81 strains or lines available

References

• Original: J:341707 Ojima K, et al., Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue. Nat Commun. 2022 Jun 16;13(1):3167
• All: 1 reference(s)