Grm1^em1Yazu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grm1^em1Yazu
• Name: glutamate receptor, metabotropic 1; endonuclease-mediated mutation 1, Michisuke Yuzaki
• MGI ID: MGI:7543449
• Synonyms: mGlu1^CBC
• Gene: Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
• Alliance: Grm1^em1Yazu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination using guide RNA induced an A to C mutation at position 790 resulting in an N to H substitution at amino acid 264. The protein produced by this allele is activated by the metal complex Pd(bpy). (J:341707)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm1 Mutation: 81 strains or lines available

References

• Original: J:341707 Ojima K, et al., Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue. Nat Commun. 2022 Jun 16;13(1):3167
• All: 1 reference(s)