Circsry^em1Why
Endonuclease-mediated Allele Detail

Summary

• Symbol: Circsry^em1Why
• Name: Sry circular RNA; endonuclease-mediated mutation 1, Haoyi Wang
• MGI ID: MGI:7541482
• Gene: Circsry Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Circsry^em1Why page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISRP/Cas9 technology deleted the 11 bp (GTTCAGCATTT) region harboring the splice acceptor site upstream of Sry coding region, leading to complete loss of circSRY. (J:331366)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Circsry Mutation: 0 strains or lines available

References

• Original: J:331366 Song Y, et al., Loss of circSRY reduces gammaH2AX level in germ cells and impairs mouse spermatogenesis. Life Sci Alliance. 2023 Feb;6(2)
• All: 1 reference(s)