Adgrl1^tm1Ush
Targeted Allele Detail

Summary

• Symbol: Adgrl1^tm1Ush
• Name: adhesion G protein-coupled receptor L1; targeted mutation 1, Yuri Ushkaryov
• MGI ID: MGI:7541365
• Gene: Adgrl1 Location: Chr8:84626734-84668583 bp, + strand Genetic Position: Chr8, 40.22 cM
• Alliance: Adgrl1^tm1Ush page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341520
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP-flanked PGK-neomycin resistance gene replaced the 3.3-kb intron between exons 1 and 2, disrupting the open reading frame. Western blot analysis confirmed the absence of protein in the brain. (J:341520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adgrl1 Mutation: 61 strains or lines available

References

• Original: J:341520 Vitobello A, et al., ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model. Am J Hum Genet. 2022 Aug 4;109(8):1436-1457
• All: 1 reference(s)