Eftud2^em3Lajm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eftud2^em3Lajm
• Name: elongation factor Tu GTP binding domain containing 2; endonuclease-mediated mutation 3, Loydie Anne Jerome-Majewska
• MGI ID: MGI:7541263
• Synonyms: Eftud2^loxP
• Gene: Eftud2 Location: Chr11:102729299-102771811 bp, - strand Genetic Position: Chr11, 66.48 cM
• Alliance: Eftud2^em3Lajm page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs inserted EcoRI and loxP sites upstream of exon 2 and EcoRV and loxP sites downstream of exon 2. (J:306031)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eftud2 Mutation: 61 strains or lines available

References

• Original: J:306031 Beauchamp MC, et al., Mutation in Eftud2 causes craniofacial defects in mice via mis-splicing of Mdm2 and increased P53. Hum Mol Genet. 2021 May 28;30(9):739-757
• All: 1 reference(s)