Dguok^m1
Chemically induced Allele Detail

Summary

• Symbol: Dguok^m1
• Name: deoxyguanosine kinase; mutation 1
• MGI ID: MGI:7541211
• Synonyms: Dguok^F180S
• Gene: Dguok Location: Chr6:83457199-83483887 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Dguok^m1 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a c.539T>C mutation, changing phenylalanine codon 180 (TTC) in exon 4 to serine (TCC) (p.F180S). The mutation is associated with a mild form of MDDS (mitochondrial DNA depletion syndrome). (J:277595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dguok Mutation: 13 strains or lines available

References

• Original: J:277595 Perez-Rivas LG, et al., Genetic characterization of a mouse line with primary aldosteronism. J Mol Endocrinol. 2017 Feb;58(2):67-78
• All: 2 reference(s)