Vdac1^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Vdac1^em1Bcgen
• Name: voltage-dependent anion channel 1; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7540465
• Gene: Vdac1 Location: Chr11:52251905-52280224 bp, + strand Genetic Position: Chr11, 31.86 cM
• Alliance: Vdac1^em1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 2-8. (J:341494)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdac1 Mutation: 66 strains or lines available

References

• Original: J:341494 Wang J, et al., VDAC1 negatively regulates melanogenesis through the Ca(2+)-calcineurin-CRTC1-MITF pathway. Life Sci Alliance. 2022 Oct;5(10):e202101350
• All: 1 reference(s)