Gpr83^{tm1.1(cre/ERT2)Ddg}
Targeted Allele Detail

Summary

• Symbol: Gpr83^{tm1.1(cre/ERT2)Ddg}
• Name: G protein-coupled receptor 83; targeted mutation 1.1, David D Ginty
• MGI ID: MGI:7539709
• Synonyms: Gpr83^CreERT2
• Gene: Gpr83 Location: Chr9:14771506-14782085 bp, + strand Genetic Position: Chr9, 4.4 cM, cytoband A2-A3
• Alliance: Gpr83^{tm1.1(cre/ERT2)Ddg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297417
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gpr83^{tm1.1(cre/ERT2)Ddg} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gpr83 (MGI:95712)

• Mutation details: A Cre recombinase-estrogen receptor T2 (CreERT2) fusion cassettes were introduced via homologous recombination into the Gpr83 genes, replacing the first coding ATG. The neomycin selection cassette was removed by recombination. (J:297417)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gpr83 (mouse) Summary of all recombinase alleles driven by Gpr83. Comparative matrix view of recombinase activities Alliance mouse Gpr83 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr83 Mutation: 23 strains or lines available

References

• Original: J:297417 Choi S, et al., Parallel ascending spinal pathways for affective touch and pain. Nature. 2020 Nov;587(7833):258-263
• All: 1 reference(s)