Plaa^tm2.1Chopa
Targeted Allele Detail

Summary

• Symbol: Plaa^tm2.1Chopa
• Name: phospholipase A2, activating protein; targeted mutation 2.1, Ashok K Chopra
• MGI ID: MGI:7539702
• Synonyms: Plaa^KO
• Gene: Plaa Location: Chr4:94455751-94491481 bp, - strand Genetic Position: Chr4, 43.34 cM
• Alliance: Plaa^tm2.1Chopa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250427
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-7 were replaced with a loxP-flanked neomycin selection cassette. The selection cassette was removed vie Cre-mediated recombination. (J:250427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plaa Mutation: 45 strains or lines available

References

• Original: J:250427 Falik Zaccai TC, et al., Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. Brain. 2017 Feb;140(2):370-386
• All: 1 reference(s)