Zswim8^em#Dpbl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zswim8^em#Dpbl
• Name: zinc finger SWIM-type containing 8; endonuclease-mediated mutation, David P Bartel
• MGI ID: MGI:7539525
• Gene: Zswim8 Location: Chr14:20757620-20773687 bp, + strand Genetic Position: Chr14, 11.53 cM, cytoband B
• Alliance: Zswim8^em#Dpbl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting exon 2 generated three small deletion and one small insertion alleles. This record includes four alleles containing a 1-bp deletion, a 7-bp deletion, a 4-bp deletion, and a 2-bp insertion. No phenotypic differences are seen between these four mutant lines so they were combined and the pound symbol (#) is used because the lines are pooled. (J:338969)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zswim8 Mutation: 52 strains or lines available

References

• Original: J:338969 Shi CY, et al., ZSWIM8 destabilizes many murine microRNAs and is required for proper embryonic growth and development. Genome Res. 2023 Aug 2
• All: 1 reference(s)