Bcl11b^tm1Itan
Targeted Allele Detail

Summary

• Symbol: Bcl11b^tm1Itan
• Name: B cell leukemia/lymphoma 11B; targeted mutation 1, Ichiro Taniuchi
• MGI ID: MGI:7539432
• Synonyms: Bcl11b^fl
• Gene: Bcl11b Location: Chr12:107876662-107969861 bp, - strand Genetic Position: Chr12, 59.1 cM, cytoband F1
• Alliance: Bcl11b^tm1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254770
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was placed adjacent to exon 4 and a loxP site was placed in the other flanking intron. (J:254770)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11b Mutation: 46 strains or lines available

References

• Original: J:254770 Kojo S, et al., Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes. Nat Commun. 2017 Sep 26;8(1):702
• All: 3 reference(s)