Tg(Ccr2-cre)584Hohl
Transgene Detail

Summary

• Symbol: Tg(Ccr2-cre)584Hohl
• Name: transgene insertion 584, Tobias M Hohl
• MGI ID: MGI:7539279
• Synonyms: CCR2-Cre
• Transgene: Tg(Ccr2-cre)584Hohl Location: unknown
• Alliance: Tg(Ccr2-cre)584Hohl page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Ccr2-cre)584Hohl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ccr2 (MGI:106185)

• Mutation details: The Cre expression cassette including the stop codon was inserted into the BAC clone RP23-182D4 containing the endogenous murine Ccr2 locus downstream of the Ccr2 promoter. The endogenous Ccr2 gene was disrupted resulting in frameshift. Four potential founder mice were identified. The lineage of one of these founders (#584) was established. (J:341212)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ccr2 (mouse) Summary of all recombinase alleles driven by Ccr2. Comparative matrix view of recombinase activities Alliance mouse Ccr2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:341212 Heung LJ, et al., Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans. PLoS Pathog. 2019 Mar;15(3):e1007627
• All: 2 reference(s)