Casp1^em1Kflds
Endonuclease-mediated Allele Detail

Summary

• Symbol: Casp1^em1Kflds
• Name: caspase 1; endonuclease-mediated mutation 1, Katherine I Swenson-Fields
• MGI ID: MGI:7539171
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^em1Kflds page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• TALEN-targeting of exon 6 generated a null allele. (J:337557)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 43 strains or lines available

References

• Original: J:337557 Swenson-Fields KI, et al., Caspase-1 and the inflammasome promote polycystic kidney disease progression. Front Mol Biosci. 2022;9:971219
• All: 1 reference(s)