Wnt4^em1Mtac
Endonuclease-mediated Allele Detail

Summary

• Symbol: Wnt4^em1Mtac
• Name: wingless-type MMTV integration site family, member 4; endonuclease-mediated mutation 1, Makoto Tachibana
• MGI ID: MGI:7539157
• Gene: Wnt4 Location: Chr4:137004946-137026812 bp, + strand Genetic Position: Chr4, 69.8 cM
• Alliance: Wnt4^em1Mtac page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 2 generated a null allele. (J:338020)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt4 Mutation: 23 strains or lines available

References

• Original: J:338020 Okashita N, et al., CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice. Proc Natl Acad Sci U S A. 2023 May 16;120(20):e2221499120
• All: 1 reference(s)