In(2Itga6;Igs15)3Ddu
Targeted Allele Detail

Summary

• Symbol: In(2Itga6;Igs15)3Ddu
• Name: inversion, Chr 2, Denis Duboule 3
• MGI ID: MGI:7537001
• Synonyms: In(2Itga6-Igs15)3Ddu, Inv(Itga6-Attp)
• Gene: In(2Itga6;Igs15)3Ddu Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239094
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (No functional change)
• Mutation: Inversion
• Mutation details: Mice with the Itga6^tm1Son allele containing a single loxP site between exons 24 and 26 in cis on chromosome 2 and Igs15^tm1.1Ddu, which also contains a loxP site integrated 3' of Hoxd1, were crossed to Hprt^tm1(cre)Mnn mice. Cre expression resulted in inversion of a segment of chromosome 2 containing exon 26 of Itga6 and the attp site 3' of Hoxd1. (J:239094)

Expression

In Mice Carrying this Mutation:

8 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any In(2Itga6;Igs15)3Ddu Mutation: 0 strains or lines available

References

• Original: J:239094 Schep R, et al., Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7720-E7729
• All: 2 reference(s)