Igf1^em2Ispgl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igf1^em2Ispgl
• Name: insulin-like growth factor 1; endonuclease-mediated mutation 2, Ivo Spiegel
• MGI ID: MGI:7532539
• Synonyms: Igf1-E12/3 cKO
• Gene: Igf1 Location: Chr10:87694127-87772904 bp, + strand Genetic Position: Chr10, 43.7 cM
• Alliance: Igf1^em2Ispgl page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Using CRISPR/Cas9 technology, two Lox2722 sequences were inserted to flank both E2 and E3 together in Igf1^tm1Ispglline described in J:341100 in which the exon1 is flanked by LoxP sites and additionally includes a Neo cassette flanked by Frt sites. (J:341100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf1 Mutation: 25 strains or lines available

References

• Original: J:341100 Roethler O, et al., Single genomic enhancers drive experience-dependent GABAergic plasticity to maintain sensory processing in the adult cortex. Neuron. 2023 Sep 6;111(17):2693-2708.e8
• All: 1 reference(s)