Parp1^em1Zqw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Parp1^em1Zqw
• Name: poly (ADP-ribose) polymerase family, member 1; endonuclease-mediated mutation 1, Zhao-Qi Wang
• MGI ID: MGI:7531482
• Synonyms: PARP1^deltaC
• Gene: Parp1 Location: Chr1:180396456-180428564 bp, + strand Genetic Position: Chr1, 84.44 cM, cytoband H5
• Alliance: Parp1^em1Zqw page

Mutation origin

• Strain of Origin: C57BL/6JRj

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 8 bp in exon 22 located 11 bp upstream from the GAG codon encoding E988. The frameshift introduction of a premature TAA stop codon in exon 22 causing the loss of the C-terminus. (J:340903)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parp1 Mutation: 68 strains or lines available

References

• Original: J:340903 Kamaletdinova T, et al., Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not Compatible with Mouse Development. Cells. 2023 Aug 16;12(16)
• All: 1 reference(s)