Tet1^tm1.1Jhha
Targeted Allele Detail

Summary

• Symbol: Tet1^tm1.1Jhha
• Name: tet methylcytosine dioxygenase 1; targeted mutation 1.1, Jacob H Hanna
• MGI ID: MGI:7529792
• Synonyms: Tet1^flox
• Gene: Tet1 Location: Chr10:62640349-62723242 bp, - strand Genetic Position: Chr10, 32.48 cM
• Alliance: Tet1^tm1.1Jhha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286905
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites. The inserted FRT-flanked neomycin selection cassette was removed via flp-mediated recombination. (J:286905)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet1 Mutation: 147 strains or lines available

References

• Original: J:286905 Zviran A, et al., Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules. Cell Stem Cell. 2019 Feb 7;24(2):328-341.e9
• All: 2 reference(s)