Eif2ak3^em1Plxu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Eif2ak3^em1Plxu
• Name: eukaryotic translation initiation factor 2 alpha kinase 3; endonuclease-mediated mutation 1, Pinglong Xu
• MGI ID: MGI:7529465
• Synonyms: Perk^-
• Gene: Eif2ak3 Location: Chr6:70821499-70882229 bp, + strand Genetic Position: Chr6, 32.09 cM
• Alliance: Eif2ak3^em1Plxu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology using gRNA 5-TGGACAGGAGGTGCCTCGTTGGG-3 targeted exon 1. (J:340415)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif2ak3 Mutation: 51 strains or lines available

References

• Original: J:340415 Zhang D, et al., A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis. Nat Cell Biol. 2022 May;24(5):766-782
• All: 1 reference(s)