Grem1^{em1(Hbegf/tdTomato)Dlwo}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grem1^{em1(Hbegf/tdTomato)Dlwo}
• Name: gremlin 1, DAN family BMP antagonist; endonuclease-mediated mutation 1, Daniel Worthley
• MGI ID: MGI:7529431
• Synonyms: Grem1-DTR-TdT
• Gene: Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
• Alliance: Grem1^{em1(Hbegf/tdTomato)Dlwo} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• CRISPR-targeting inserted a Diptheria toxin Receptor (DTR)/tdTomato (tdTom) into exon 2. (J:340408)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grem1 Mutation: 20 strains or lines available

References

• Original: J:340408 Ng JQ, et al., Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis. bioRxiv. 2023
• All: 1 reference(s)