Foxn3^em2Liju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Foxn3^em2Liju
• Name: forkhead box N3; endonuclease-mediated mutation 2, Juntang Lin
• MGI ID: MGI:7526577
• Synonyms: Foxn3^KI
• Gene: Foxn3 Location: Chr12:99156337-99529841 bp, - strand Genetic Position: Chr12, 49.93 cM, cytoband F1
• Alliance: Foxn3^em2Liju page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated non-synonymous serine to alanine conversions at residues 83 and 85. These changes disrupt phosphorylation at these sites. (J:340225)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn3 Mutation: 32 strains or lines available

References

• Original: J:340225 Zhu X, et al., p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-kappaB signaling pathway. Nucleic Acids Res. 2023 Mar 21;51(5):2195-2214
• All: 1 reference(s)