Dlk1^tm1.1Wwz
Targeted Allele Detail

Summary

• Symbol: Dlk1^tm1.1Wwz
• Name: delta like non-canonical Notch ligand 1; targeted mutation 1.1, Wenwen Zeng
• MGI ID: MGI:7526522
• Synonyms: Dlk1^fl
• Gene: Dlk1 Location: Chr12:109418749-109429262 bp, + strand Genetic Position: Chr12, 60.17 cM, cytoband E-F1
• Alliance: Dlk1^tm1.1Wwz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340171
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank the exons 36 of the gene. FLP-mediated recombination resulted in the removal of the neomycin cassette in the germline. (J:340171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlk1 Mutation: 36 strains or lines available

References

• Original: J:340171 Hu Z, et al., DLK mediates the neuronal intrinsic immune response and regulates glial reaction and neuropathic pain. Exp Neurol. 2019 Dec;322:113056
• All: 1 reference(s)