Cbx1^tm1.1Hko
Targeted Allele Detail

Summary

• Symbol: Cbx1^tm1.1Hko
• Name: chromobox 1; targeted mutation 1.1, Haruhiko Koseki
• MGI ID: MGI:7526291
• Gene: Cbx1 Location: Chr11:96679953-96699466 bp, + strand Genetic Position: Chr11, 60.11 cM
• Alliance: Cbx1^tm1.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:370951
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A pair of loxP flanked exon 2 and exon 3. Flp-mediated recombination removed the selection cassette. (J:104881)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cbx1 Mutation: 91 strains or lines available

References

• Original: J:370951 Newman AG, et al., Glial reactivity and cognitive decline follow chronic heterochromatin loss in neurons. Nat Commun. 2025 Aug 8;16(1):7325
• All: 2 reference(s)