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SufuRgsc2027
Chemically induced Allele Detail
Summary
Symbol: SufuRgsc2027
Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2027
MGI ID: MGI:7525857
Synonyms: SufuE260K
Gene: Sufu  Location: Chr19:46385335-46477243 bp, + strand  Genetic Position: Chr19, 38.85 cM
Alliance: SufuRgsc2027 page
Mutation
origin
Strain of Origin:  C57BL/6JJcl
Mutation
description
Allele Type:    Chemically induced (ENU) (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis introduced the point mutation responsible for the amino acid substitution glutamic acid with lysine at position 260 (E260K). (J:228335)
Inheritance:    Dominant
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sufu Mutation:  59 strains or lines available
References
Original:  J:228335 Makino S, et al., T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One. 2015;10(3):e0119455
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory