Sufu^Rgsc2027
Chemically induced Allele Detail

Summary

• Symbol: Sufu^Rgsc2027
• Name: SUFU negative regulator of hedgehog signaling; RIKEN Genomic Sciences Center, 2027
• MGI ID: MGI:7525857
• Synonyms: Sufu^E260K
• Gene: Sufu Location: Chr19:46385335-46477243 bp, + strand Genetic Position: Chr19, 38.85 cM
• Alliance: Sufu^Rgsc2027 page

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis introduced the point mutation responsible for the amino acid substitution glutamic acid with lysine at position 260 (E260K). (J:228335)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sufu Mutation: 59 strains or lines available

References

• Original: J:228335 Makino S, et al., T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor. PLoS One. 2015;10(3):e0119455
• All: 1 reference(s)