Nlrc4^em1Swca
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nlrc4^em1Swca
• Name: NLR family, CARD domain containing 4; endonuclease-mediated mutation 1, Scott W. Canna
• MGI ID: MGI:7525747
• Synonyms: NLRC4^T337S
• Gene: Nlrc4 Location: Chr17:74733254-74766140 bp, - strand Genetic Position: Chr17, 45.64 cM
• Alliance: Nlrc4^em1Swca page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced a coding region modification (T337S) found in macrophage activation syndrome (MAS) in human. (J:261562)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc4 Mutation: 72 strains or lines available

References

• Original: J:261562 Weiss ES, et al., Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome. Blood. 2018 Mar 29;131(13):1442-1455
• All: 3 reference(s)