Gpr149^em1Xxi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpr149^em1Xxi
• Name: G protein-coupled receptor 149; endonuclease-mediated mutation 1, Xin Xie
• MGI ID: MGI:7525712
• Gene: Gpr149 Location: Chr3:62436851-62512861 bp, - strand Genetic Position: Chr3, 29.97 cM
• Alliance: Gpr149^em1Xxi page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Intragenic deletion, Nucleotide substitutions
• CRISPR/Cas9 technology generated a 20 nucleotide deletion and an 8 nucleotide mutation in exon 1. (J:340028)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr149 Mutation: 37 strains or lines available

References

• Original: J:340028 Suo N, et al., The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Glia. 2022 Oct;70(10):1992-2008
• All: 1 reference(s)