Icos^tm1Ymi
Targeted Allele Detail

Summary

• Symbol: Icos^tm1Ymi
• Name: inducible T cell co-stimulator; targeted mutation 1, Yasushi Miyahira
• MGI ID: MGI:7525663
• Synonyms: ICOS-
• Gene: Icos Location: Chr1:61017086-61039479 bp, + strand Genetic Position: Chr1, 30.6 cM
• Alliance: Icos^tm1Ymi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257100
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The partial of exon 2 was replaced with a neomycin-resistance gene by homologous recombination. (J:257100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icos Mutation: 30 strains or lines available

References

• Original: J:257100 Miyahira Y, et al., Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett. 2003 Oct 31;89(2-3):193-9
• All: 2 reference(s)