Wdr77^em1Fhou
Endonuclease-mediated Allele Detail

Summary

• Symbol: Wdr77^em1Fhou
• Name: WD repeat domain 77; endonuclease-mediated mutation 1, Fajian Hou
• MGI ID: MGI:7525292
• Synonyms: Wdr77^fl
• Gene: Wdr77 Location: Chr3:105866814-105877076 bp, + strand Genetic Position: Chr3, 46.46 cM
• Alliance: Wdr77^em1Fhou page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Through CRISPR-Cas9-mediated gene editing, two loxP sites were inserted to flank the fifth to ninth exons of the Wdr77 gene. (J:338972)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr77 Mutation: 17 strains or lines available

References

• Original: J:338972 Li J, et al., WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response. Nat Commun. 2023 Aug 10;14(1):4824
• All: 1 reference(s)