Gsdmd^tm1.2Tshir
Targeted Allele Detail

Summary

• Symbol: Gsdmd^tm1.2Tshir
• Name: gasdermin D; targeted mutation 1.2, Toshihiko Shiroishi
• MGI ID: MGI:7525157
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^tm1.2Tshir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140319
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A frt-flanked neomycin selection cassette with a single loxP site at the 3' end was inserted into intron 2 and an additional loxP site was inserted 1.95 kb upstream of exon 1. Flp-mediated recombination removed the selection cassette. (J:140319)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 35 strains or lines available

References

• Original: J:140319 Fujii T, et al., Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development. Genesis. 2008 Aug;46(8):418-23
• All: 6 reference(s)