Stxbp1^{tm1.1(STXBP1)Bpro}
Targeted Allele Detail

Summary

• Symbol: Stxbp1^{tm1.1(STXBP1)Bpro}
• Name: syntaxin binding protein 1; targeted mutation 1.1, Benjamin Prosser
• MGI ID: MGI:7524737
• Synonyms: STXBP1 hu
• Gene: Stxbp1 Location: Chr2:32677619-32737249 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Stxbp1^{tm1.1(STXBP1)Bpro} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Stxbp1^{tm1.1(STXBP1)Bpro} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  STXBP1 (6812)

  Stxbp1

  (MGI:107363)

• Mutation details: The targeting vector contains from 5' to 3' a loxP site, an FRT-flanked neomycin cassette, a human genomic DNA BAC encoding STXBP1 gene, an F3-flanked hygromycin, followed by a second loxP site used to replace the endogenous murine sequence from approximately 5.4kb upstream of exon 1 through to near to the end of exon 19 with the human genomic region from approximately 4.0kb upstream of exon 1 (Transcript ENST00000373299.5) through to the end of the final exon of human transcript ENST00000636962.2. This humanized region may also express the short 35 residue isoform of PTRH1 (Uniprot: A0A286YER0) on chromosome 2. The insertion results in a knock-out of Stxbp1. Flp-mediated recombination removed the neo and hygro cassettes. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stxbp1 Mutation: 47 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)