Spp1^tm1.1Jkbs
Targeted Allele Detail

Summary

• Symbol: Spp1^tm1.1Jkbs
• Name: secreted phosphoprotein 1; targeted mutation 1.1, Tatjana C Jakobs
• MGI ID: MGI:7524675
• Synonyms: Spp1^GFPfl
• Gene: Spp1 Location: Chr5:104582984-104588916 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Spp1^tm1.1Jkbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335751
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to contain (from 5' to 3';) a loxP site and a self-excising neomycin selection cassette placed upstream of exon 4, an enhanced green fluorescent protein sequence, a stop cassette, a second loxP site, and a tdTomato sequence with a stop cassette placed downstream of exon 7. (J:335751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spp1 Mutation: 45 strains or lines available

References

• Original: J:335751 Li S, et al., Secreted phosphoprotein 1 slows neurodegeneration and rescues visual function in mouse models of aging and glaucoma. Cell Rep. 2022 Dec 27;41(13):111880
• All: 1 reference(s)