Hgfac^em1Mher
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hgfac^em1Mher
• Name: hepatocyte growth factor activator; endonuclease-mediated mutation 1, Mark A Herman
• MGI ID: MGI:7524575
• Gene: Hgfac Location: Chr5:35198853-35205805 bp, + strand Genetic Position: Chr5, 17.99 cM
• Alliance: Hgfac^em1Mher page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISRP/Cas9 technology generated an 857 bp deletion spanning mid exon 1 and exon 2. (J:339849)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgfac Mutation: 26 strains or lines available

References

• Original: J:339849 Sargsyan A, et al., HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. JCI Insight. 2023 Jan 10;8(1)
• All: 1 reference(s)