Adra1a^em2Afu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adra1a^em2Afu
• Name: adrenergic receptor, alpha 1a; endonuclease-mediated mutation 2, Akiyoshi Fukamizu
• MGI ID: MGI:7524375
• Gene: Adra1a Location: Chr14:66872700-67008617 bp, + strand Genetic Position: Chr14, 34.6 cM, cytoband D1
• Alliance: Adra1a^em2Afu page

Mutation origin

• Strain of Origin: ICR

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a deletion-insertion frameshift mutation (2 bp deletion, 3 bp insertion) close to the start codon resulting in a STOP codon. (J:339785)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adra1a Mutation: 32 strains or lines available

References

• Original: J:339785 Kim JD, et al., Increased angiotensin II coupled with decreased Adra1a expression enhances cardiac hypertrophy in pregnancy-associated hypertensive mice. J Biol Chem. 2023 Feb 2;299(3):102964
• All: 1 reference(s)