Stmp1^em1Xia
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stmp1^em1Xia
• Name: short transmembrane mitochondrial protein 1; endonuclease-mediated mutation 1, Mengqing Xiang
• MGI ID: MGI:7524238
• Synonyms: 181-Rik^-
• Gene: Stmp1 Location: Chr6:35229645-35238574 bp, + strand Genetic Position: Chr6, 15.26 cM
• Alliance: Stmp1^em1Xia page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology replaced most of exon 2 and the entire exon 3 with a GFP sequence. While abundant expression of GFP transcripts is seen, no GFP protein is detected in retinas by Western blotting or immunostaining. (J:339742)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stmp1 Mutation: 6 strains or lines available

References

• Original: J:339742 Zheng X, et al., A lncRNA-encoded mitochondrial micropeptide exacerbates microglia-mediated neuroinflammation in retinal ischemia/reperfusion injury. Cell Death Dis. 2023 Feb 15;14(2):126
• All: 1 reference(s)