Mcam^em1Dlwo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mcam^em1Dlwo
• Name: melanoma cell adhesion molecule; endonuclease-mediated mutation 1, Daniel L Worthley
• MGI ID: MGI:7523899
• Gene: Mcam Location: Chr9:44045958-44054024 bp, + strand Genetic Position: Chr9, 24.68 cM
• Alliance: Mcam^em1Dlwo page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 935 bp deletion that includes exons 2-4. This causes a frameshift resulting in a premature stop codon in exon 6. (J:321199)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcam Mutation: 38 strains or lines available

References

• Original: J:321199 Kobayashi H, et al., The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis. Gastroenterology. 2022 Mar;162(3):890-906
• All: 1 reference(s)