Usp18^tm2Dez
Targeted Allele Detail

Summary

• Symbol: Usp18^tm2Dez
• Name: ubiquitin specific peptidase 18; targeted mutation 2, Dong-Er Zhang
• MGI ID: MGI:7523179
• Synonyms: Usp18^fl
• Gene: Usp18 Location: Chr6:121222865-121247876 bp, + strand Genetic Position: Chr6, 57.17 cM, cytoband F
• Alliance: Usp18^tm2Dez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339515
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin selection cassette was inserted upstream of exon 2 and a third loxP site was inserted downstream of exon 3. (J:339515)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp18 Mutation: 25 strains or lines available

References

• Original: J:339515 Arimoto KI, et al., Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Nat Commun. 2023 Jan 17;14(1):251
• All: 2 reference(s)