Tg(ACTA1-Slk*K63R)3405Lasa
Transgene Detail

Summary

• Symbol: Tg(ACTA1-Slk*K63R)3405Lasa
• Name: transgene insertion 3405, Luc Sabourin
• MGI ID: MGI:7522473
• Synonyms: Tg(HSA-Slk*K63R)3405
• Transgene: Tg(ACTA1-Slk*K63R)3405Lasa Location: unknown
• Alliance: Tg(ACTA1-Slk*K63R)3405Lasa page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-Slk*K63R)3405Lasa expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Slk (MGI:103241)

• Tg(ACTA1-Slk*K63R)3405Lasa expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTA1 (58)

  Acta1

  (MGI:87902)

• Mutation details: The transgene contains the human skeletal actin promoter, mouse SLK mutated gene (upstream of full-length kinase-inactive SLK bearing a point mutation at lysine 63), and HA (hemagglutinin) tag sequence. Line 654 and 3405 Tg mice have a high and low expression level of K63R, respectively. (J:339424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:339424 Storbeck CJ, et al., Distinct roles for Ste20-like kinase SLK in muscle function and regeneration. Skelet Muscle. 2013;3(1):16
• All: 1 reference(s)