Gt(ROSA)26Sor^{tm12(Hes1)Imayo}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm12(Hes1)Imayo}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 12, Itaru Imayoshi
• MGI ID: MGI:7522459
• Synonyms: Gt(ROSA)26Sor^{tm1(Hes1,EGFP)Imayo}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm12(Hes1)Imayo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203419
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm12(Hes1)Imayo} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hes1 (MGI:104853)

• Mutation details: The targeting construct inserted into the locus an adenovirus splice acceptor sequence (SA), Bacteriophage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), neomycin resistance gene (E. coli), SV40 late polyA signal, mouse Hes1 cDNA, EMCV (Encephalomyocarditis virus) internal ribosomal entry site (IRES), Jellyfish EGFP cDNA, and bovine GH polyA. (J:203419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:203419 Imayoshi I, et al., Oscillatory control of factors determining multipotency and fate in mouse neural progenitors. Science. 2013 Dec 6;342(6163):1203-8
• All: 2 reference(s)