Pole^em1Utbr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pole^em1Utbr
• Name: polymerase (DNA directed), epsilon; endonuclease-mediated mutation 1, Uri Tabori
• MGI ID: MGI:7520535
• Synonyms: Pole^P286R
• Gene: Pole Location: Chr5:110434185-110485319 bp, + strand Genetic Position: Chr5, 53.45 cM, cytoband E3-E5
• Alliance: Pole^em1Utbr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of proline with arginine at position 286 (P286R). (J:339146)

Tumor Data

List all tumor models in MMHCdb carrying Pole^em1Utbr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pole Mutation: 103 strains or lines available

References

• Original: J:339146 Galati MA, et al., Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade. Cancer Res. 2020;80(24):5606-5618
• All: 2 reference(s)