Tg(Tff2-Hbegf,-cre/ERT2)#Tcw
Transgene Detail

Summary

• Symbol: Tg(Tff2-Hbegf,-cre/ERT2)#Tcw
• Name: transgene insertion, Timothy C Wang
• MGI ID: MGI:7520440
• Synonyms: Tff2-DTR-CreER^T2
• Transgene: Tg(Tff2-Hbegf,-cre/ERT2)#Tcw Location: unknown
• Alliance: Tg(Tff2-Hbegf,-cre/ERT2)#Tcw page

Transgene origin

• Strain of Origin: CBA x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Tff2-Hbegf,-cre/ERT2)#Tcw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Tg(Tff2-Hbegf,-cre/ERT2)#Tcw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tff2 (MGI:1306805)

• Mutation details: Using recombineering methods, the DTR-CreERT2-FrtNeoFrt cassette was inserted at the ATG codon in exon 1 of the Tff2 gene in the BAC RP24-335C16. The modified BAC construct was injected into fertilized CBA x C57BL/6J oocytes. The modified BAC construct was injected into fertilized CBA x C57BL/6J oocytes. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:338908)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tff2 (mouse) Summary of all recombinase alleles driven by Tff2. Comparative matrix view of recombinase activities Alliance mouse Tff2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:338908 Jiang Z, et al., Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis. Cell Stem Cell. 2023 Aug 3;30(8):1091-1109.e7
• All: 1 reference(s)