Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh
Transgene Detail

Summary

• Symbol: Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh
• Name: transgene insertion 1, Makoto Kinoshita
• MGI ID: MGI:7520423
• Synonyms: Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh
• Transgene: Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh Location: unknown
• Alliance: Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sirt1 (MGI:2135607)

• Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh expression driven by 2 genes
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cryaa (MGI:88515)
  mouse	Prnp (MGI:97769)

• Mutation details: PrP-Sirt1 transgene has a mouse Sirt1 gene under the control of mouse prion gene promoter (MoPrP). The MoPrP-Sirt1 transcription unit was co-injected with a mouse alpha A-crystallin promoter-driven EGFP cDNA. (J:339147)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:339147 Watanabe S, et al., SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system. Mol Brain. 2014 Aug 29;7:62
• All: 2 reference(s)