Hk1^em1Hard
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hk1^em1Hard
• Name: hexokinase 1; endonuclease-mediated mutation 1, Hossein Ardehali
• MGI ID: MGI:7520369
• Synonyms: deltaE1HK1
• Gene: Hk1 Location: Chr10:62104634-62215687 bp, - strand Genetic Position: Chr10, 32.37 cM
• Alliance: Hk1^em1Hard page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination replaced the N-terminal mitochondrial binding domain in exon 1 with a Flag-tag. (J:339135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hk1 Mutation: 57 strains or lines available

References

• Original: J:339135 De Jesus A, et al., Hexokinase 1 cellular localization regulates the metabolic fate of glucose. Mol Cell. 2022 Apr 7;82(7):1261-1277.e9
• All: 1 reference(s)