Sufu^tm1.1Hui
Targeted Allele Detail

Summary

• Symbol: Sufu^tm1.1Hui
• Name: SUFU negative regulator of hedgehog signaling; targeted mutation 1.1, Chi-chung Hui
• MGI ID: MGI:7520232
• Gene: Sufu Location: Chr19:46385335-46477243 bp, + strand Genetic Position: Chr19, 38.85 cM
• Alliance: Sufu^tm1.1Hui page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151923
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 4-8 were surrounded by loxP sites. A neomycin selection cassette was inserted as well. The loxP -flanked region and the neomycin selection cassette were removed in the germline via Cre-mediated recombination. (J:151923)

Expression

In Mice Carrying this Mutation:

52 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sufu Mutation: 59 strains or lines available

References

• Original: J:151923 Chen MH, et al., Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009 Aug 15;23(16):1910-28
• All: 5 reference(s)