Tg(Gsta1-NFE2L2/Venus)F4Tiw
Transgene Detail

Summary

• Symbol: Tg(Gsta1-NFE2L2/Venus)F4Tiw
• Name: transgene insertion F4, Takao Iwawaki
• MGI ID: MGI:7520188
• Synonyms: Tg(3xARE/TK-NRF2/venus)F4Tiw
• Transgene: Tg(Gsta1-NFE2L2/Venus)F4Tiw Location: unknown Genetic Position: ChrUN, Syntenic
• Alliance: Tg(Gsta1-NFE2L2/Venus)F4Tiw page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Gsta1-NFE2L2/Venus)F4Tiw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NFE2L2 (4780)

  Nfe2l2

  (MGI:108420)

• Tg(Gsta1-NFE2L2/Venus)F4Tiw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gsta1 (MGI:1095417)

• Mutation details: The transgene contains the 3xARE promoter (mouse anxioxidant/electrophile responsive element, herpes simplex virus TK basal promoter), human Nrf2(1-433) cDNA, Aequorea victoria venus (GFP) cDNA, FLAG tag, SV40 t intron, SV40 enhancer+ori, SV40 polyA signal, and Polyomavirus enhancer+ori. (J:212112)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:212112 Takagi T, et al., Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury. Free Radic Biol Med. 2014 Jul;72:124-33
• All: 1 reference(s)