Gipr^tm1.2Dajl
Targeted Allele Detail

Summary

• Symbol: Gipr^tm1.2Dajl
• Name: gastric inhibitory polypeptide receptor; targeted mutation 1.2, David Lloyd
• MGI ID: MGI:7519131
• Synonyms: Gipr KO
• Gene: Gipr Location: Chr7:18889986-18900052 bp, - strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gipr^tm1.2Dajl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268644
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 4 and 5 are flanked by loxP sites, and a positive selection marker (Puromycin resistance) flanked by frt sites was inserted into intron 5, then subsequently removed via FLP-mediated recombination in the germline. Further Cre-mediated recombination in the germline resulted in the deletion of exons 4 and 5. (J:268644)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gipr Mutation: 28 strains or lines available

References

• Original: J:268644 Killion EA, et al., Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models. Sci Transl Med. 2018 Dec 19;10(472)
• All: 2 reference(s)